Angiogenesis, the process of new blood vessel formation, is an essential requirement for the survival and proliferation of solid tumors. Accordingly, the search for angiogenesis inhibitors has become a leading line of investigation in anticancer research, and it has translated into several drugs in the market that have clearly improved outcomes in patients with different tumor types and metastatic disease. However, several limitations still exist, such as the lack of efficacy in some patients...
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