Ion channels are key elements of the plasmatic membranes. They are constituted as homo- or heteromeric protein complexes and selectively mediate the ion flux through the lipid bilayer to keep a gradient between both sides of the membrane. Cells make use of this gradient to regulate basic functions and, as a consequence, deregulation or abnormal functioning of ion channels are responsible for severe pathologies. Thus, and as a general approach, the modulation of such ion channels is crucial to...
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